Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Nature Communications2015Vol. 6(1), pp. 7138–7138
Citations Over TimeTop 1% of 2015 papers
Fredrick R. Schumacher, Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, Shu-Chen Huang, Christopher P. Fischer, John F. Harju, Gregory Idos, Flavio Lejbkowicz, Frank J. Manion, Kevin McDonnell, Caroline McNeil, Marilena Melas, Hedy S. Rennert, Wei Shi, Duncan C. Thomas, David Van Den Berg, Carolyn M. Hutter, Aaron K. Aragaki, Katja Butterbach, Bette J. Caan, Christopher S. Carlson, Stephen J. Chanock, Keith R. Curtis, Charles S. Fuchs, Manish Gala, Edward L. Giovannucci, Stephanie M. Gogarten, Richard B. Hayes, Brian E. Henderson, David J. Hunter, Rebecca D. Jackson, Laurence N. Kolonel, Charles Kooperberg, Sébastien Küry, Andrea Z. LaCroix, Cathy C. Laurie, Cecelia Laurie, Mathieu Lemire, David Levine, Jing Ma, Karen W. Makar, Conghui Qu, Darin Taverna, Cornelia M. Ulrich, Kana Wu, Suminori Kono, Dee W. West, Sonja I. Berndt, Stéphane Bezieau, Hermann Brenner, Peter T. Campbell, Andrew T. Chan, Jenny Chang‐Claude, Gerhard A. Coetzee, David V. Conti, David Duggan, Jane C. Figueiredo, Barbara K. Fortini, Steven Gallinger, W. James Gauderman, Graham G. Giles, Roger Green, Robert W. Haile, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, Eric J. Jacobs, Motoki Iwasaki, Sun Ha Jee, Mark A. Jenkins, Wei-Hua Jia, Amit D. Joshi, Li Li, Noralene M. Lindor, Keitaro Matsuo, Vı́ctor Moreno, Bhramar Mukherjee, Polly A. Newcomb, John D. Potter, Leon Raskin, Gad Rennert, Stephanie A. Rosse, Gianluca Severi, Robert E. Schoen, Daniela Seminara, Xiao‐Ou Shu, Martha L. Slattery, Shoichiro Tsugane, Emily White, Yong-Bing Xiang, Brent W. Zanke, Wei Zheng, Loı̈c Le Marchand, Graham Casey, Stephen B. Gruber, Ulrike Peters
Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
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