International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Nature Communications2015Vol. 6(1), pp. 8019–8019
Citations Over TimeTop 1% of 2015 papers
Heather J. Cordell, Younghun Han, George Mells, Yafang Li, Gideon M. Hirschfield, Casey S. Greene, Gang Xie, Brian D. Juran, Dakai Zhu, David C. Qian, James Floyd, Katherine I. Morley, Daniele Prati, Ana Lleò, Daniele Cusi, Erik M. Schlicht, Craig Lammert, Elizabeth J. Atkinson, Landon L. Chan, Mariza de Andrade, Tobias Balschun, Andrew L. Mason, Robert P. Myers, Jinyi Zhang, Piotr Milkiewicz, Jia Qu, Joseph A. Odin, Velimir A. Luketic, Bruce R. Bacon, Henry C. Bodenheimer, Valentina Liakina, Catherine Vincent, Cynthia Levy, Peter K. Gregersen, Italian PBC Genetics Study Group, Piero Luigi Almasio, Domenico Alvaro, Pietro Andreoné, Angelo Andriulli, Cristina Barlassina, Pier Maria Battezzati, A. Benedetti, Francesca Bernuzzi, Ilaria Bianchi, Maria Consiglia Bragazzi, Maurizia Rossana Brunetto, Savino Bruno, Giovanni Casella, B. Coco, Agostino Colli, Massimo Colombo, Sílvia Colombo, Carmela Cursaro, Lory Saveria Crocè, Andrea Crosignani, Maria Francesca Donato, G. Elia, Luca Fabris, Carlo Ferrari, Annarosa Floreani, Barbara Foglieni, Rosanna Fontana, Andrea Galli, Roberta Lazzari, Fabio Salvatore Macaluso, Federica Malinverno, Fabio Marra, Marco Marzioni, Alberto Mattalia, R. Montanari, Lorenzo Morini, Filomena Morisco, Hani S. Mousa, Luigi Muratori, Paolo Muratori, Grazia Anna Niro, Vincenzo Ostilio Palmieri, A. Picciotto, Mauro Podda, Piero Portincasa, Vincenzo Ronca, F. Rosina, Sonia Rossi, Ilaria Sogno, Giancarlo Spinzi, Marta Spreafico, Mario Strazzabosco, Sonia Tarallo, Mirko Tarocchi, Claudio Tiribelli, Pierluigi Toniutto, Maria Cristina Vinci, Massimo Zuin, Chin Lye Ch’ng, Mesbah Rahman, Tom Yapp, Richard Sturgess, Christopher Healey, Marek Czajkowski, Anton Gunasekera, Pranab Gyawali, Purushothaman Premchand, Kapil Kapur, Richard Marley, Graham R. Foster, Alan Watson, Aruna Dias, Javaid Subhani, Rory Harvey, Roger McCorry, David Ramanaden, Jaber Gasem, Richard Evans, Thiriloganathan Mathialahan, C Shorrock, George Lipscomb, Paul Southern, Jeremy Tibble, Stephen Gorard, Altaf Palegwala, Susan Jones, Marco Carbone, Mohamed Dawwas, Graeme Alexander, Sunil Dolwani, Martin Prince, Matthew Foxton, David Elphick, Harriet Mitchison, Ian Gooding, Mazn Karmo, Sushma Saksena, Mike Mendall, Minesh Patel, Roland Ede, Andrew Austin, Joanna Sayer, Lorraine Hankey, Christopher Hovell, Neil Fisher, Martyn Carter, Konrad Koss, Andrzej Piotrowicz, Charles Grimley, David E. Neal, Guan Lim, Sass Levi, Aftab Ala, Andrea Broad, Athar A. Saeed, Gordon Wood, Jonathan Brown, Mark Wilkinson, Harriet Gordon, John Ramage, Jo Ridpath, Theodore Ngatchu, Bob Grover, Syed Shahid Shaukat, Ray Shidrawi, George Abouda, Faiz Ali, Ian Rees, Imroz Salam, Mark Narain, Ashley Brown, Simon D. Taylor‐Robinson, Simon Williams, Leonie Grellier, Paul Banim, Debasish Das, Andrew Chilton, Michael A. Heneghan, Howard J. Curtis, Markus Gess, Ian Drake, Mark Aldersley, Mervyn H. Davies, Rebecca Jones, Alastair McNair, Raj Srirajaskanthan, Maxton Pitcher, Sambit Sen, George Bird, Adrian Barnardo, Paul Kitchen, Kevin Yoong, Oza Chirag, Nurani Sivaramakrishnan, George MacFaul, David Jones, Amir Shah, Chris Evans, Subrata Saha, Katharine Pollock, Peter Bramley, Ashis Mukhopadhya, Andrew Fraser, Peter R. Mills, Christopher Shallcross, S. Campbell, Andrew Bathgate, Alan Shepherd, John Dillon, Simon Rushbrook, Robert Przemioslo, Christopher Macdonald, Jane Metcalf, Udi Shmueli, A. Davis, Asifabbas Naqvi, Tom Lee, Stephen Ryder, Jane Collier, Howard Klass, Mary Ninkovic, Matthew Cramp, Nicholas M. 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Holder, Caroline Palmer, James Featherstone, Mariam Nasseri, Joy Sadeghian, Bronwen Williams, Carol Thomas, Sally-Ann Rolls, Abigail Hynes, Claire Duggan, Sarah Jones, Mary M.E. Crossey, Glynis Stansfield, Carolyn MacNicol, Joy Wilkins, Elva Wilhelmsen, Parizade Raymode, Hye‐Jeong Lee, Emma Durant, Rebecca Bishop, Noma Ncube, Sherill Tripoli, Rebecca M. Casey, Caroline Cowley, Richard A. Miller, Kathryn Houghton, Samantha Ducker, Fiona Wright, Bridget Bird, Gwen Baxter, Janie Keggans, Maggie Hughes, Emma Grieve, Karin Young, Dewi Williams, Kate Ocker, Frances Hines, K. Martin, Caron Innes, Talal Valliani, Helen Fairlamb, Sarah Thornthwaite, Anne Eastick, Elizabeth Tanqueray, Jennifer Morrison, Becky Holbrook, Julie Browning, Kirsten Walker, Susan Congreave, Juliette Verheyden, Susan Slininger, Lizzie Stafford, Denise O’Donnell, Mark Ainsworth, Susan Lord, Linda Kent, Linda March, Christine Dickson, Diane M. 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Warner, Kimberley Netherton, McDonald Mupudzi, Bridget Gunson, Jane Gitahi, Denise Gocher, Sally Batham, Hilary Pateman, Senayon Desmennu, Jill Conder, Darren Clement, Susan Gallagher, Jacky Orpe, PuiChing Chan, Lynn Currie, L O’Donohoe, Metod Oblak, Lisa Morgan, Marie Quinn, Isobel Amey, Yolanda Baird, Donna Cotterill, Lourdes Cumlat, Louise Winter, Sandra Greer, Katie Spurdle, Joanna Allison, Simon Dyer, Helen Sweeting, Jean Kordula, M. Eric Gershwin, Carl A. Anderson, Konstantinos N. Lazaridis, Pietro Invernizzi, Michael F. Seldin, Richard Sandford, Christopher I. Amos, Katherine A. Siminovitch
Abstract
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist.
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