Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Nature Communications2015Vol. 6(1), pp. 8658–8658
Citations Over TimeTop 10% of 2015 papers
María Soler Artigas, Louise V. Wain, S. Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ιωάννα Ντάλλα, Nick Shrine, Ma’en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Wei Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan Marten, Stefan Enroth, Ida Surakka, Ozren Polašek, Leo‐Pekka Lyytikäinen, Raquel Granell, Pirro G. Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry‐Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R. González, Harald Grallert, Christopher J. Hammond, Sarah E. Harris, Anna‐Liisa Hartikainen, Markku Heliövaara, John Henderson, Lynne J. Hocking, Momoko Horikoshi, Nina Hutri‐Kähönen, Erik Ingelsson, Åsa Johansson, John P. Kemp, Ivana Kolčić, Ashish Kumar, Lars Lind, Erik Melén, Arthur W. Musk, Pau Navarro, David C. Nickle, Sandosh Padmanabhan, Olli T. Raitakari, Janina S. Ried, Samuli Ripatti, Holger Schulz, Robert A. Scott, Don D. Sin, John M. Starr, UK BiLEVE, Panos Deloukas, Anna L. Hansell, Richard Hubbard, Victoria E. Jackson, Jonathan Marchini, Ian Pavord, Neil C. Thomson, Eleftheria Zeggini, Ana Viñuela, Henry Völzke, Philipp S. Wild, Alan F. Wright, Tatijana Zemunik, Deborah Jarvis, Tim D Spector, David M. Evans, Terho Lehtimäki, Véronique Vitart, Mika Kähönen, Ulf Gyllensten, Igor Rudan, Ian J. Deary, Stefan Karrasch, Nicole M Probst-Hensch, Joachim Heinrich, Beate Stubbe, James F Wilson, Nicholas J. Wareham, Alan L James, Andrew P Morris, Marjo‐Riitta Järvelin, Caroline Hayward, Ian Sayers, David P Strachan, Ian P. Hall, Martin D. Tobin
Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Related Papers
- → Imputation of ancient human genomes(2023)97 cited
- → Assessing HLA imputation accuracy in a West African population(2023)3 cited
- → HLA imputation in an admixed population: An assessment of the 1000 Genomes data as a training set(2015)29 cited
- → Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels(2012)21 cited
- → Imputation of ancient genomes(2022)4 cited