Cytokinin response factors regulate PIN-FORMED auxin transporters
Citations Over TimeTop 1% of 2015 papers
Abstract
Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.
Related Papers
- → Antagonistic activity of auxin and cytokinin in shoot and root organs(2019)75 cited
- → Auxin and cytokinin regulate each other’s levels via a metabolic feedback loop(2011)48 cited
- → Cytokinin Inhibits a Subset of Diageotropica-Dependent Primary Auxin Responses in Tomato(2003)42 cited
- → Separation of two responses to auxin by means of cytokinin inhibition.(1975)83 cited
- → Root formation in pea cuttings: Effects of combined application of auxin and cytokinin at different developmental stages(1980)6 cited