The Genotype-Tissue Expression (GTEx) project
Nature Genetics2013Vol. 45(6), pp. 580–585
Citations Over TimeTop 16% of 2013 papers
John T. Lonsdale, Jeffrey A. Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz, Gary Walters, Fernando U. Garcia, Nancy Young, Barbara A. Foster, Mike Moser, Ellen Karasik, Bryan M. Gillard, Kimberley D. Ramsey, Susan Sullivan, Jason Bridge, Harold I. Magazine, John Syron, Johnelle Fleming, Laura A. Siminoff, Heather M. Traino, Maghboeba Mosavel, Laura K. Barker, Scott D. Jewell, Dan Rohrer, Dan Maxim, Dana Filkins, P.R. Harbach, Eddie Cortadillo, Bree D. Berghuis, Lisa Turner, Eric A. Hudson, Kristin Feenstra, Leslie H. Sobin, J Robb, Phillip Branton, Greg E. Korzeniewski, Charles Shive, David E. Tabor, Liqun Qi, Kevin Groch, Sreenath Nampally, Steve Buia, Angela Zimmerman, Anna M. Smith, Robin Burges, Karna Robinson, Kim Valentino, Deborah Bradbury, Mark Cosentino, Norma Diaz-Mayoral, Mary Kennedy, Theresa Engel, Penelope Williams, Kenyon Erickson, Kristin G. Ardlie, Wendy Winckler, Gad Getz, David S. DeLuca, Daniel G. MacArthur, Manolis Kellis, Alexander Thomson, Taylor Young, Ellen Gelfand, Molly Donovan, Yan Meng, George Grant, Deborah C. Mash, Yvonne Marcus, Margaret J. Basile, Jun Liu, Jun Zhu, Zhidong Tu, Nancy J. Cox, Dan L. Nicolae, Eric R. Gamazon, Hae Kyung Im, Anuar Konkashbaev, Jonathan K. Pritchard, Matthew Stevens, Timothée Flutre, Xiaoquan Wen, Emmanouil T. Dermitzakis, Tuuli Lappalainen, Roderic Guigó, Jean Monlong, Michael Sammeth, Daphne Koller, Alexis Battle, Sara Mostafavi, Mark I. McCarthy, Manual Rivas, Julian Maller, Ivan Rusyn, Andrew B. Nobel, Fred A. Wright, Andrey A. Shabalin, Mike Feolo, Nataliya Sharopova, Anne Sturcke, Justin Paschal, James M. Anderson, Elizabeth L. Wilder, Leslie Derr, Eric D. Green, Jeffery P. Struewing, Gary Temple, Simona Volpi, Joy T Boyer, Elizabeth J. Thomson, Mark S. Guyer, Cathy Ng, Assya Abdallah, Deborah Colantuoni, Thomas R. Insel, Susan E. Koester, A Roger Little, Patrick K. Bender, Thomas Lehner, Yin Yao, Carolyn C. Compton, Jimmie B. Vaught, Sherilyn J. Sawyer, Nicole C. Lockhart, Joanne P. Demchok, Helen Moore
Abstract
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.