Literature-curated protein interaction datasets
Nature Methods2008Vol. 6(1), pp. 39–46
Citations Over TimeTop 1% of 2008 papers
Michael E. Cusick, Haiyuan Yu, Alex Smolyar, K. Venkatesan, Anne‐Ruxandra Carvunis, Nicolas Simonis, Jean‐François Rual, Heather Borick, Pascal Falter‐Braun, Matija Dreze, Jean Vandenhaute, Mary Galli, Junshi Yazaki, David E. Hill, Joseph R. Ecker, Frederick P. Roth, Marc Vidal
Abstract
High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.
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