The Adipose Tissue Phenotype of Hormone‐Sensitive Lipase Deficiency in Mice
Obesity Research2001Vol. 9(2), pp. 119–128
Citations Over TimeTop 1% of 2001 papers
Shu Pei Wang, Nancy Laurin, Jean Himms‐Hagen, Michael A. Rudnicki, Emile Levy, Marie‐France Robert, Linghe Pan, Luc L. Oligny, Grant A. Mitchell
Abstract
In isolated fat cells, the lipolytic rate after beta-adrenergic stimulation is mainly dependent on HSL. However, the observation of a normal rate of lipolysis in unstimulated HSL-/- adipocytes suggests that HSL-independent lipolytic pathway(s) exist in fat. Physiologically, HSL deficiency in mice has a modest effect under normal fed conditions and is compatible with normal maintenance of core body temperature during cold stress. However, the lipolytic response to overnight fasting is subnormal.
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