Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence
Obesity Research2002Vol. 10(6), pp. 478–488
Citations Over TimeTop 10% of 2002 papers
Carlo Colantuoni, Pedro Rada, Joseph McCarthy, Caroline S. Patten, Nicole M. Avena, Andrew Chadeayne, Bartley G. Hoebel
Abstract
Repeated, excessive intake of sugar created a state in which an opioid antagonist caused behavioral and neurochemical signs of opioid withdrawal. The indices of anxiety and DA/ACh imbalance were qualitatively similar to withdrawal from morphine or nicotine, suggesting that the rats had become sugar-dependent.
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