Effect of Carbohydrate Overfeeding on Whole Body and Adipose Tissue Metabolism in Humans
Obesity Research2003Vol. 11(9), pp. 1096–1103
Citations Over TimeTop 22% of 2003 papers
Kaori Minehira, Vincent Bettschart, Hubert Vidal, Nathalie Véga, Véronique Di Vetta, Valentine Rey, Philippe Schneiter, Luc Tappy
Abstract
Carbohydrate overfeeding markedly increased net de novo lipogenesis at the expense of glycogen synthesis. An increase in mRNAs coding for key lipogenic enzymes suggests that de novo lipogenesis occurred, at least in part, in adipose tissue. The pentose-phosphate pathway is active in adipose tissue of healthy humans, consistent with an active role of this tissue in de novo lipogenesis.
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