Diet Induction of Monocyte Chemoattractant Protein‐1 and its Impact on Obesity
Obesity Research2005Vol. 13(8), pp. 1311–1320
Citations Over TimeTop 10% of 2005 papers
Airu Chen, Sheena Mumick, Chunsheng Zhang, John R. Lamb, Hongyue Dai, Drew T. Weingarth, John S. Mudgett, Howard Chen, Douglas J. MacNeil, Marc L. Reitman, Su Qian
Abstract
A high-fat diet elevated adipose expression of inflammatory genes, including early induction of MCP-1 and MCP-3, supporting the view that obese adipose tissues contribute to systemic inflammation. However, despite increased MCP-1 in obesity, disruption of MCP-1 signaling did not confer resistance to DIO in mice or reduce adipose tissue macrophage infiltration.
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