Differential Regulation of Adiponectin Receptor Gene Expression by Adiponectin and Leptin in Myotubes Derived from Obese and Diabetic Individuals
Obesity2006Vol. 14(11), pp. 1898–1904
Citations Over TimeTop 10% of 2006 papers
Andrew J. McAinch, Gregory R. Steinberg, Janelle P. Mollica, Paul E. O’Brien, John B. Dixon, S. Lance Macaulay, Bruce E. Kemp, David Cameron‐Smith
Abstract
Adiponectin and leptin are rapid and potent stimulators of AdipoR1 in myotubes derived from lean healthy individuals. This effect was abolished in myotubes derived from obese, obese diabetic subjects, and obese-prone individuals who had lost significant weight after bariatric surgery. The incapacity of skeletal muscle of obese and diabetic individuals to respond to exogenous adiponectin and leptin may be further suppressed as a result of impaired regulation of the AdipoR1 gene.
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