G‐2548A Polymorphism of the Leptin Gene Is Correlated with Extreme Obesity in Taiwanese Aborigines
Obesity2006Vol. 14(2), pp. 183–187
Citations Over TimeTop 10% of 2006 papers
Tsu‐Nai Wang, Meng‐Chuan Huang, Wen‐Tsan Chang, Albert Min‐Shan Ko, Eing‐Mei Tsai, Chih‐Shan Liu, Chien‐Hung Lee, Ying‐Chin Ko
Abstract
We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity. Two hundred twenty-six obese aboriginal subjects (BMI > or = 27 kg/m2) and 182 aboriginal subjects with normal weight (BMI or = 35 kg/m2) than in normal weight subjects (6.9%) but not in moderately obese subjects (35 > BMI > or = 27 kg/m2). There was no difference in genotypic frequency of the LEPR Q223R polymorphism between the extreme obese and control groups. We suggest that the LEP -2548 G/G homozygote plays a genetic recessive role in the development of extreme obesity in Taiwanese aborigines.
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