Assessment of Diet‐induced Obese Rats as an Obesity Model by Comparative Functional Genomics
Obesity2008Vol. 16(4), pp. 811–818
Citations Over TimeTop 10% of 2008 papers
Shuyu Li, Hongyan Zhang, Charlie C. Hu, Frank Lawrence, Kelly E. Gallagher, Anupama Surapaneni, Shawn T. Estrem, John Calley, Gábor Varga, Ernst R. Dow, Yanyun Chen
Abstract
Our study based on gene-expression profiling suggested that DIO rats in general represent an appropriate obesity model. However, the discrepancies in gene-expression alterations between DIO rats and obese humans, particularly in the metabolic pathways, may explain the limitations of using DIO rodent models in obesity research and drug discovery.
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