Viral Mediated Neuropeptide Y Expression in the Rat Paraventricular Nucleus Results in Obesity
Obesity2007Vol. 15(10), pp. 2424–2435
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Birgitte Tiesjema, Susanne E. la Fleur, Mieneke C. M. Luijendijk, Maike A. D. Brans, En‐Ju D. Lin, Matthew J. During, Roger A.H. Adan
Abstract
These data suggest that increased NPY expression targeted at the PVN is sufficient to induce obesity. Interestingly, plasma concentrations of leptin and insulin were elevated before a rise in food intake, which suggests that NPY in the PVN influences leptin and insulin secretion independently from food intake. This strengthens the role of the PVN in regulation of energy balance by NPY.
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