Deriving dopaminergic neurons for clinical use. A practical approach
Scientific Reports2013Vol. 3(1), pp. 1463–1463
Citations Over TimeTop 10% of 2013 papers
Rodolfo Gonzalez, Ibon Garitaonandia, Tatiana Abramihina, Gerald Wambua, Alina Ostrowska, Mathew Brock, Alexander Noskov, Francesca S. Boscolo, John S. Craw, Louise C. Laurent, Evan Y. Snyder, Ruslan Semechkin
Abstract
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.
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