GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
Scientific Reports2013Vol. 3(1), pp. 3075–3075
Citations Over TimeTop 13% of 2013 papers
Patrick Sleiman, Dai Wang, Joseph Glessner, Dexter Hadley, Raquel E. Gur, Nadine Cohen, Qingqin S. Li, Håkon Håkonarson, the Janssen-CHOP Neuropsychiatric Genomics Working Group, Patrick Sleiman, Joseph Glessner, Dexter Hadley, Charlly Kao, Zhi-liang Wu, Cecilia Kim, Kelly Thomas, Håkon Håkonarson, Dai Wang, Reyna Favis, Dong-Jing Fu, Hedy Chung, Adam Savitz, Srihari Gopal, Nadine Cohen, Qingqin S. Li
Abstract
We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(-9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.
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