Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism

Citations Over TimeTop 10% of 2014 papers

Abstract

Acupoint stimulations are effective in ameliorating symptoms of menopause which is an unavoidable ageing consequence for women. To understand the mechanistic aspects of such treatments, we systematically analyzed the effects of acupoint laser-irradiation and catgut-embedding on the ovariectomy-induced rat metabolic changes using NMR and GC-FID/MS methods. Results showed that ovariectomization (OVX) caused comprehensive metabolic changes in lipid peroxidation, glycolysis, TCA cycle, choline and amino acid metabolisms. Both acupoint laser-irradiation and catgut-embedding ameliorated the OVX-caused metabonomic changes more effectively than hormone replacement therapy (HRT) with nilestriol. Such effects of acupoint stimulations were highlighted in alleviating lipid peroxidation, restoring glucose homeostasis and partial reversion of the OVX-altered amino acid metabolism. These findings provided new insights into the menopause effects on mammalian biochemistry and beneficial effects of acupoint stimulations in comparison with HRT, demonstrating metabonomics as a powerful approach for potential applications in disease prognosis and developments of effective therapies.

Related Papers

• → Alternatives to hormone replacement therapy: A multi-method study of women's experiences(2006)31 cited
• → Women's perceptions of the effects of menopause and hormone replacement therapy on skin(2011)13 cited
• → Hormone replacement therapy: post‐menopausal sex life and attitudes towards sex(2005)9 cited
• [Actual experiences of menopause in 342 women].(2000)
• Effect of oestrogen replacement therapy on bone mass in post-menopausal Bangladeshi women.(2001)