DNA methylome in spleen of avian pathogenic escherichia coli-challenged broilers and integration with mRNA expression
Citations Over TimeTop 10% of 2014 papers
Abstract
Avian pathogenic Escherichia coli (APEC) are responsible for heavy economic losses in poultry industry. Here we investigate DNA methylome of spleen and identify functional DNA methylation changes related to host response to APEC among groups of non-challenged chickens (NC), challenged with mild (MD) and severe pathology (SV). DNA methylation was enriched in the gene bodies and repeats. Promoter and CGIs are hypomethylated. Integration analysis revealed 22, 87, and 9 genes exhibiting inversely changed DNA methylation and gene expression in NC vs. MD, NC vs. SV, and MD vs. SV, respectively. IL8, IL2RB, and IL1RAPL1 were included. Gene network analysis suggested that besides inflammatory response, other networks and pathways such as organismal injury and abnormalities, cell signaling and molecular transport, are probably related to host response to APEC infection. Moreover, methylation changes in cell cycle processes might contribute to the lesion phenotype differences between MD and SV.
Related Papers
- → Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation(2008)340 cited
- → Global methylation profiles in DNA from different blood cell types(2011)132 cited
- → New DNA Methylation Markers and Global DNA Hypomethylation Are Associated with Oral Cancer Development(2015)76 cited
- → Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues(2010)47 cited
- → Changes of DNA methylation of Isoetes sinensis under Pb and Cd stress(2018)15 cited