One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging, drug delivery and catalysis

Citations Over TimeTop 15% of 2014 papers

Abstract

Surface functionalized nanoparticles have found their applications in several fields including biophotonics, nanobiomedicine, biosensing, drug delivery, and catalysis. Quite often, the nanoparticle surfaces must be post-coated with organic or inorganic layers during the synthesis before use. This work reports a generally one-pot synthesis method for the preparation of various inorganic-organic core-shell nanostructures (Au@polymer, Ag@polymer, Cu@polymer, Fe3O4@polymer, and TiO2@polymer), which led to new optical, magnetic, and catalytic applications. This green synthesis involved reacting inorganic precursors and poly(styrene-alt-maleic acid). The polystyrene blocks separated from the external aqueous environment acting as a hydrophobic depot for aromatic drugs and thus illustrated the integration of functional nanoobjects for drug delivery. Among these nanocomposites, the Au@polymer nanoparticles with good biocompatibility exhibited shell-dependent signal enhancement in the surface plasmon resonance shift, nonlinear fluorescence, and surface-enhanced Raman scattering properties. These unique optical properties were used for dual-modality imaging on the delivery of the aromatic photosensitizer for photodynamic therapy to HeLa cells.

Related Papers

• → Exploiting nanoparticles as precursors for novel nanostructure designs and properties(2012)30 cited
• Carbon encapsulated magnetic nanoparticles produced by hydrothermal reaction(2007)
• Structural and chemical changes in the topochemical 1,4-polymerization of 3,4-bis(methylene)hexanedioic acid(2012)
• Structure and Magnetic Properties of S-doped Mn_3O_4/S Composited Nanoparticles and Mn_3O_4 Nanoparticles(2011)
• → SAFE-SHELL: A COMPUTER PROGRAM FOR THE STRESS ANALYSIS OF THIN-SHELL BODIES OF REVOLUTION. A USER'S MANUAL.(1967)