Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma
Citations Over TimeTop 18% of 2015 papers
Abstract
The most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility and efficacy of concurrent chemoradiotherapy (CCRT), mostly with three-weekly or four-weekly schedule of chemotherapy. However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities. Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center. Twenty-seven consecutive patients who were diagnosed with postoperative locoregional recurrence of oesophageal squamous cell carcinoma and received CCRT with weekly chemotherapy of 5-FU and platinum agents were retrospectively analyzed. Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.
Related Papers
- → A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis(2001)63 cited
- → Folinic Acid Does Improve 5-Fluorouracil ActivityIn Vivo.Results of a Phase III Study Comparing 5-Fluorouracil to 5-Fluorouracil and Folinic Acid in Advanced Colon Cancer Patients(1993)22 cited
- 5-Fluorouracil,Leucovorin and Carmofur Combination in Treatment for Advanced Large-intestinal Cancer(2001)
- Study on N~1-Hydroxyalkyl-5-Fluorouracils and α-5-Fluorouracil-N~1-Dicarboxylic Acids(1990)
- → A Prospective Randomised Multicentre Phase III Clinical Trial Comparing the Effects of Panorex Injection Plus 5-Fluorouracil (5-FU)/Leucovorin versus 5-Fluorouracil/Leucovorin versus PANOREX alone, in patients with Surgically resected Stage III (Dukes C) Carcinoma of the Colon(2012)