Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection
Citations Over TimeTop 10% of 2015 papers
Abstract
Herpes simplex virus-1 (HSV-1) is a double-stranded DNA virus that causes life-long infections. HSV-1 infections may lead to herpetic stromal keratitis that may advance to corneal blindness. HSV-1 infections can also cause fatal conditions, such as herpes encephalitis, or neonatal disease. A major virulence mechanism of HSV-1 is the control of autophagy, an innate immune defense strategy that could otherwise degrade viral particles. Here, to investigate a new mechanism for antiviral therapy, we tested the effect of various autophagy inducers (physiological and pharmacological) on infection. Autophagy stimulation was confirmed to significantly suppress HSV-1 infection in various cell types, without affecting cell viability. This study establishes the importance of autophagy for regulating HSV-1 infection, and provides a proof-of-principle evidence for a novel antiviral mechanism.
Related Papers
- → Investigation of vesicular rashes for HSV and VZV by PCR(1998)54 cited
- → Monoclonal antibodies for the identification of herpesvirus simiae (B virus)(1992)19 cited
- → Suppression of generation and replication of acyclovir‐resistant herpes simplex virus by a sensitive virus(2003)18 cited
- → Studies of the Enhancement of an Adenovirus-associated Virus by Herpes Simplex Virus(1971)24 cited
- → Further characterization of virus obtained from herpes simplex virus type 1 recurrences and primary infections. Influence of the temperature of incubation upon glycoprotein synthesis and virus release(1986)7 cited