An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning

Citations Over Time

Abstract

Odor detection applications are needed by human societies in various circumstances. Rodent offers unique advantages in developing biologic odor detection systems. This report outlines a novel apparatus designed to train maximum 5 mice automatically to detect odors using a new olfactory, relative go no-go, operant conditioning paradigm. The new paradigm offers the chance to measure real-time reliability of individual animal's detection behavior with changing responses. All of 15 water-deprivation mice were able to learn to respond to unpredictable delivering of the target odor with higher touch frequencies via a touch sensor. The mice were continually trained with decreasing concentrations of the target odor (n-butanol), the average correct percent significantly dropped when training at 0.01% solution concentration; the alarm algorithm showed excellent recognition of odor detection behavior of qualified mice group through training. Then, the alarm algorithm was repeatedly tested against simulated scenario for 4 blocks. The mice acted comparable to the training period during the tests, and provided total of 58 warnings for the target odor out of 59 random deliveries and 0 false alarm. The results suggest this odor detection method is promising for further development in respect to various types of odor detection applications.

Related Papers

• → Augmentation of taste conditioning by a preconditioned odor.(1999)36 cited
• → Analysis of odor in car cabin(1999)14 cited
• → Differences in taste-potentiated odor aversions with O+/OT+ versus OT+/O+ conditioning: Implications for configural associations(2008)6 cited
• → Backward Conditioning, Cessation Conditioning, Two-Way Conditioning--and the Classical-Operant Dichotomy(1966)
• [Discriminating stimulus, conditioning and strategy during operant conditioning].(1969)