High Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element
Scientific Reports2015Vol. 5(1), pp. 10086–10086
Citations Over TimeTop 10% of 2015 papers
Meng Ye, Pingping Lv, Guolian Ding, Tiantian Yu, Ye Liu, Yan Shen, Xiao Hu, Xian-Hua Lin, Shen Tian, Min Lv, Yang Song, Mengxi Guo, Zhang-Hong Ke, Hong Xu, Jian‐Zhong Sheng, Feng-Tao Shi, Hefeng Huang
Abstract
OS can induce a high maternal E2 environment, which up-regulates HMGCR expression in fetal hepatocytes via an ERE in the promoter, and induces elevated levels of TC and LDL-C in newborns that may be related to increased risk of metabolic disease in adulthood.
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