Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
Scientific Reports2015Vol. 5(1), pp. 12131–12131
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Abstract
This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
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