Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
Scientific Reports2015Vol. 5(1), pp. 14055–14055
Citations Over TimeTop 1% of 2015 papers
Bo Zheng, Tandis Vazin, Patrick Goodwill, Anthony Conway, Aradhana Verma, Emine Ülkü Sarıtaş, David V. Schaffer, Steven Conolly
Abstract
We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.
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