Donkey genome and insight into the imprinting of fast karyotype evolution
Citations Over TimeTop 10% of 2015 papers
Abstract
The donkey, like the horse, is a promising model for exploring karyotypic instability. We report the de novo whole-genome assemblies of the donkey and the Asiatic wild ass. Our results reflect the distinct characteristics of donkeys, including more effective energy metabolism and better immunity than horses. The donkey shows a steady demographic trajectory. We detected abundant satellite sequences in some inactive centromere regions but not in neocentromere regions, while ribosomal RNAs frequently emerged in neocentromere regions but not in the obsolete centromere regions. Expanded miRNA families and five newly discovered miRNA target genes involved in meiosis may be associated with fast karyotype evolution. APC/C, controlling sister chromatid segregation, cytokinesis, and the establishment of the G1 cell cycle phase were identified by analysis of miRNA targets and rapidly evolving genes.
Related Papers
- → Donkey and mule behaviour for the veterinary team(2019)11 cited
- → A Functional Assay for Centromere-Associated Sister Chromatid Cohesion(1999)72 cited
- Summary of development of donkey husbandry and donkey meat processing industry in China(2009)
- The Challenge and Opportunity of the Development of Donkey Industry in Xinjiang(2014)
- → Re: Do You Want to Be a Donkey?(2022)