Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
Scientific Reports2015Vol. 5(1), pp. 14613–14613
Citations Over TimeTop 10% of 2015 papers
Jess Nithianantharajah, Andrew G. McKechanie, Tiffany Stewart, Mandy Johnstone, Douglas Blackwood, David St Clair, Seth G. N. Grant, Timothy J. Bussey, Lisa M. Saksida
Abstract
Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
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