Oscillating high-aspect-ratio monolithic silicon nanoneedle array enables efficient delivery of functional bio-macromolecules into living cells
Scientific Reports2015Vol. 5(1), pp. 15325–15325
Citations Over TimeTop 10% of 2015 papers
Daisuke Matsumoto, Ramachandra Rao Sathuluri, Yoshio Kato, Yaron Silberberg, Ryuzo Kawamura, Futoshi Iwata, Takeshi Kobayashi, Chikashi Nakamura
Abstract
Delivery of biomolecules with use of nanostructures has been previously reported. However, both efficient and high-throughput intracellular delivery has proved difficult to achieve. Here, we report a novel material and device for the delivery of biomacromolecules into live cells. We attribute the successful results to the unique features of the system, which include high-aspect-ratio, uniform nanoneedles laid across a 2D array, combined with an oscillatory feature, which together allow rapid, forcible and efficient insertion and protein release into thousands of cells simultaneously.
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