ZJU index: a novel model for predicting nonalcoholic fatty liver disease in a Chinese population
Citations Over TimeTop 10% of 2015 papers
Abstract
Non-alcoholic fatty liver disease (NAFLD) is an important health issue worldwide. We aimed to develop a simple model to determine the presence of NAFLD in a Chinese population. A cross-sectional study with 9602 subjects was conducted. Potential predictors were entered into a stepwise logistic regression analysis to obtain the model. We used 148 patients with liver biopsy to validate this model. The model, named the ZJU index, was developed based on body mass index (BMI), fasting plasma glucose (FPG), triglycerides (TG), and the serum alanine aminotransferase (ALT) to serum aspartate transaminase (AST) ratio. The area under the receiver operating characteristic curve (AUROC) of the ZJU index to detect NAFLD was 0.822. At a value of 38.0, the ZJU index could detect NAFLD with a specificity of 93.4%. In patients with liver biopsy, the ZJU index could detect steatosis with good accuracy, with an AUROC of 0.896. This study revealed that the ZJU index is a helpful model to detect NAFLD for community physicians in China. It was validated not only by a validation cohort but also by pathological data.
Related Papers
- → Body mass index as a predictor of hepatic steatosis in living liver donors(2001)258 cited
- → Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation(2003)103 cited
- → Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index(2021)27 cited
- → Fluorescence spectroscopy to diagnose hepatic steatosis in a rat model of fatty liver(2009)19 cited
- → Rapid Decrease in Liver Graft Steatosis in the Early Post-transplant Period: A Blinded and Randomized Study(2019)3 cited