Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects
Citations Over TimeTop 1% of 2016 papers
Abstract
A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous three dimensional scaffolds with a compressive strength of 110 MPa. Scaffolds with hexagonal design demonstrated a high fatigue resistance (1,000,000 cycles at 1-10 MPa compressive cyclic load), failure reliability and flexural strength (30 MPa) compared with those for conventional architecture. The obtained strength is 150 times greater than values reported for polymeric and composite scaffolds and 5 times greater than reported values for ceramic and glass scaffolds at similar porosity. These scaffolds open avenues for treatment of load bearing bone defects in orthopaedic, dental and maxillofacial applications.
Related Papers
- → Fabrication design for a high-quality laser diode-based ceramic converter for a laser headlamp application(2017)57 cited
- → A multi-probe micro-fabrication apparatus based on the friction-induced fabrication method(2013)12 cited
- → Fabrication of ITER Central Solenoid Model Coil inner module(1997)7 cited
- → Effect of Fabrication Parameters on Mechanical Properties of Al<sub>2</sub>O<sub>3</sub> Ceramic Tool Materials(2008)3 cited
- → Optimization study for fabrication of micro-scale stacked dielectric elastomer actuators(2017)1 cited