Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma
Citations Over TimeTop 10% of 2016 papers
Abstract
Melanoma is a highly malignant neoplasm of melanocytes with considerable metastatic potential and drug resistance, explaining the need for new candidates that inhibit tumor growth and metastasis. The signal transducer and activator of the transcription 3 (Stat3) signaling pathway plays an important role in melanoma and has been validated as promising anticancer target for melanoma therapy. In this study, nifuroxazide, an antidiarrheal agent identified as an inhibitor of Stat3, was evaluated for its anti-melanoma activity in vitro and in vivo. It had potent anti-proliferative activity against various melanoma cell lines and could induce G2/M phase arrest and cell apoptosis. Moreover, nifuroxazide markedly impaired melanoma cell migration and invasion by down-regulating phosphorylated-Src, phosphorylated-FAK, and expression of matrix metalloproteinase (MMP) -2, MMP-9 and vimentin. It also significantly inhibited tumor growth without obvious side effects in the A375-bearing mice model by inducing apoptosis and reducing cell proliferation and metastasis. Notably, nifuroxazide significantly inhibited pulmonary metastases, which might be associated with the decrease of myeloid-derived suppressor cells (MDSCs). These findings suggested that nifuroxazide might be a potential agent for inhibiting the growth and metastasis of melanoma.
Related Papers
- → The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies(2018)121 cited
- Multi-functional roles of Stat3 revealed by conditional gene targeting.(2001)
- Effects of Signal Transducer and Activator of Transcription 3 on the Tumorigenesis(2009)
- Effect of signal transducer and activator of transcription 3 in neoplasms invasion and metastasis(2010)
- Signal transducers and activators of transcription 3 signaling pathway in the pathogenesis and treatment of psoriasis(2013)