Type 1 Diabetes at-risk children highly recognize Mycobacterium avium subspecies paratuberculosis epitopes homologous to human Znt8 and Proinsulin
Scientific Reports2016Vol. 6(1), pp. 22266–22266
Citations Over TimeTop 13% of 2016 papers
Magdalena Niegowska, Novella Rapini, Simona Piccinini, Giuseppe Mameli, Elisa Caggiu, Maria Luisa Manca Bitti, Leonardo A. Sechi
Abstract
Mycobacterium avium subspecies paratuberculosis (MAP) has been previously associated to T1D as a putative environmental agent triggering or accelerating the disease in Sardinian and Italian populations. Our aim was to investigate the role of MAP in T1D development by evaluating levels of antibodies directed against MAP epitopes and their human homologs corresponding to ZnT8 and proinsulin (PI) in 54 T1D at-risk children from mainland Italy and 42 healthy controls (HCs). A higher prevalence was detected for MAP/ZnT8 pairs (62,96% T1D vs. 7,14% HCs; p 0.8) and a pairwise overlap of positivity (>83% for MAP/ZnT8).
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