Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins
Scientific Reports2016Vol. 6(1), pp. 26401–26401
Citations Over TimeTop 16% of 2016 papers
Abstract
A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus (HCV) at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized, based on a limited set of protein sequences with high sequence identity within genotypes. The identified coevolving residues constitute highly relevant predictions of protein-protein interactions for further experimental identification of HCV protein complexes. The method can be used to analyse other viral genomes and to predict the associated protein interaction networks.
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