Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice
Citations Over TimeTop 10% of 2016 papers
Abstract
The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We report a high-throughput mass spectrometry-based proteomics characterization of MAMs from mouse liver, which portrays them as an extremely complex compartment involved in different metabolic processes, including steroid metabolism. Interestingly, we identified caveolin-1 (CAV1) as an integral component of hepatic MAMs, which determine the relative cholesterol content of these ER subdomains. Finally, a detailed comparative proteomics analysis between MAMs from wild type and CAV1-deficient mice suggests that functional CAV1 contributes to the recruitment and regulation of intracellular steroid and lipoprotein metabolism-related processes accrued at MAMs. The potential impact of these novel aspects of CAV1 biology on global cell homeostasis and disease is discussed.
Related Papers
- → Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T(2013)128 cited
- → DIFFERENTIATION OF ENDOPLASMIC RETICULUM IN HEPATOCYTES(1971)276 cited
- → Morphology and function of the endoplasmic reticulum(1966)13 cited
- Endoplasmic Reticulum Stress and Liver Disease(2012)
- Endoplasmic reticulum stress and alcoholic liver disease(2009)