Purification of Nanoparticles by Size and Shape
Scientific Reports2016Vol. 6(1), pp. 27494–27494
Citations Over TimeTop 1% of 2016 papers
J. David Robertson, Loris Rizzello, Milagros Avila-Olias, Jens Gaitzsch, Claudia Contini, Monika S. Magoń, Stephen A. Renshaw, Giuseppe Battaglia
Abstract
Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.
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