Contrast-Enhanced Ultrasonography with Quantitative Analysis allows Differentiation of Renal Tumor Histotypes

Citations Over TimeTop 10% of 2016 papers

Abstract

Totally 85 patients with 93 renal lesions who underwent contrast-enhanced ultrasound (CEUS) were retrospectively studied with quantitative analysis to evaluate its value in the differential diagnosis of renal tumor histotypes. CEUS characteristics were analysed including the enhancement patterns, peak intensity, homogeneity of enhancement, and pseudocapsule. Quantitative parameters of peak intensity (P) and time to peak (TP) were measured with QontraXt software, and the index "relative enhancement percentage" ΔP% and "difference in TP between tumor and cortex" ΔTP were used to quantify the CEUS features of renal tumors. There are significant difference in CEUS features between the 46 clear cell renal cell carcinoma (CCRCC) and other types of renal tumors, including 17 low malignant lesions, 11 urothelial carcinoma of the renal pelvis, and 19 renal angiomyolipoma. The differences lie in the peak intensity, the homogeneity, the time of wash-in, peak, clearance and presence of pseudocapsule. The ΔTP and ΔP% of the CCRCC is significantly different from other tumors. With "fast to peak + high peak intensity" as the main criterion, assisted with "heterogeneous enhancement" and "fast wash-in" as the secondary criteria, the diagnostic accuracy of CCRCC is 91.4%, demonstrating quantitative CEUS imaging is highly valuable in differentiating CCRCC from other tumors.

Related Papers

• → Malignant Epithelioid Angiomyolipoma (`Sarcoma Ex Angiomyolipoma') of the Kidney(2001)170 cited
• → An unusual renal angiomyolipoma with morphological lymphangioleiomyomatosis features and coexpression of oestrogen and progesterone receptors(2001)13 cited
• → A case of angiomyolipoma of the lower lip(2013)5 cited
• Epithelioid Angiomyolipoma: An Overview of Five Cases with the Concept of PEComa(2008)
• → 1134: Renal Cell Carcinoma and Renal Angiomyolipoma: Differentiation with Contrast-Enhanced Ultrasound(2009)