0 citations0 references

High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013

Scientific Reports2016Vol. 6(1), pp. 38844–38844

Citations Over TimeTop 10% of 2016 papers

Valentino Cherubini, Edlira Skrami, Lucia Ferrito, Stefano Zucchini, Andrea Scaramuzza, Riccardo Bonfanti, Pietro Buono, Francesca Cardella, Vittoria Cauvin, Giovanni Chiari, Giuseppe d’Annunzio, Anna Paola Frongia, Dario Iafusco, Ippolita Patrizia Patera, Sonia Toni, Stefano Tumini, Ivana Rabbone, Fortunato Lombardo, Flavia Carle, Rosaria Gesuita, Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED), Riccardo Lera, L De Luna, Antonella Gualtieri, Clara Zecchino, Elvira Piccinno, Petra Reinstadler, Elena Prandi, Francesco Gallo, G Morganti, Carlo Ripoli, Alfonso La Loggia, P Scanu, Giuliana Cardinale, L. Tomaselli, Felice Citriniti, Nicola Lazzaro, Valeria Donno, Benedetta Mainetti, Maria Susanna Coccioli, Rosella Maccioni, Ugo Marongiu, Mariella Bruzzese, Antonio Iannilli, Daniela Pardi, Santino Confetto, Angela Zanfardino, Lorenzo Iughetti, Adriana Franzese, Francesco Cadario, Anna Franca Milia, Gavina Piredda, Miriam Soro, Antonella Correddu, Alfonso Galderisi, Fiorella De Berardinis, Giovanni Federico, Giorgio Zanette, Tosca Suprani, Annalisa Pedini, Maria Luisa Manca Bitti, Maurizio Delvecchio, Michela Trada, Tullio Meloni, Alberto Gaiero, Pasquale Bulciolu, L Guerraggio, Elena Faleschini, Manuela Zanatta, Alessandro Salvatoni, Claudio Maffeis, Claudia Arnaldi

Abstract

This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models were used to evaluate the time trend of DKA frequency considered as present versus absent and severe versus absent, adjusted for gender, age group and geographical area of residence at diagnosis. Overall, 9,040 cases were ascertained. DKA frequency was 40.3% (95%CI: 39.3-41.4%), with 29.1% and 11.2% for mild/moderate and severe DKA, respectively. Severe DKA increased significantly during the period (OR = 1.03, 95%CI: 1.003-1.05). Younger-age children and children living in Southern Italy compared to Central Italy were at significantly higher risk of DKA and severe DKA. Family history of type 1 diabetes and residence in Sardinia compared to Central Italy were significantly associated with a lower probability of DKA and severe DKA. The high frequency of ketoacidosis in Italy over time and high variability among age groups and geographical area of residence, strongly suggests a continuing need for nationwide healthcare strategies to increase awareness of early detection of diabetes.

Citations Over TimeTop 10% of 2016 papers

Abstract

Related Papers