A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins
Citations Over TimeTop 1% of 2017 papers
Abstract
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins αvβ3, αvβ5, αvβ6, αvβ8, α5β1, αIIbβ3, using homogenous ELISA-like solid phase binding assay.
Related Papers
- → RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS(1996)3,144 cited
- → Integrins in regulation of tissue development and function(2003)318 cited
- → Structure–Activity Relationships of RGD-Containing Peptides in Integrin αvβ5-Mediated Cell Adhesion(2023)45 cited
- → Erratum: Integrins in regulation of tissue development and function. J Pathol ; 200: 471–480(2003)192 cited
- → Syndecan‐ and integrin‐binding peptides synergistically accelerate cell adhesion(2010)30 cited