An oxygen sensitive self-decision making engineered CAR T-cell
Scientific Reports2017Vol. 7(1), pp. 39833–39833
Citations Over TimeTop 10% of 2017 papers
Alexandre Juillerat, Alan Maréchal, Jean Marie Filhol, Yannick Valogne, Julien Valton, Aymeric Duclert, Philippe Duchâteau, Laurent Poirot
Abstract
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choice of targetable antigens. By fusing an oxygen sensitive subdomain of HIF1α to a CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of certain tumors. Along with the development of oxygen-sensitive CAR T-cells, this work also provides a basic framework to use a multi-chain CAR as a platform to create the next generation of smarter self-decision making CAR T-cells.
Related Papers
- → You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy(2020)109 cited
- → Early and Late Toxicities of Chimeric Antigen Receptor T-Cells(2023)10 cited
- → Strategies for modifying the chimeric antigen receptor (CAR) to improve safety and reduce toxicity in CAR T cell therapy for cancer(2023)11 cited
- → [Prospect for chimeric antigen receptor-engineered T cell immunotherapy for solid tumors].(2018)
- → [Advances in Structural Designs of Chimeric Antigen Receptor T Cells--Review].(2022)