Low-density lipoprotein cholesterol and survival in pulmonary arterial hypertension
Citations Over TimeTop 12% of 2017 papers
Abstract
Low-density lipoprotein cholesterol(LDL-C) is a well established metabolic marker of cardiovascular risk, however, its role in pulmonary arterial hypertension (PAH) has not been determined. Therefore we assessed whether LDL-C levels are altered in PAH patients, if they are associated with survival in this group and whether pulmonary hypertension (PH) reversal can influence LDL-C levels. Consecutive 46 PAH males and 94 females were age matched with a representative sample of 1168 males and 1245 females, respectively. Cox regression models were used to assess the association between LDL-C and mortality. The effect of PH reversal on LDL-C levels was assessed in 34 patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing invasive treatment. LDL-C was lower in both PAH (2.6 ± 0.8 mmol/l) and CTEPH (2.7 ± 0.7 mmol/l) patients when compared to controls (3.2 ± 1.1 mmol/l, p < 0.001). In PAH patients lower LDL-C significantly predicted death (HR:0.44/1 mmol/l, 95%CI:0.26-0.74, p = 0.002) after a median follow-up time of 33(21-36) months. In the CTEPH group, LDL-C increased (from 2.6[2.1-3.2] to 4.0[2.8-4.9]mmol/l, p = 0.01) in patients with PH reversal but remained unchanged in other patients (2.4[2.2-2.7] vs 2.3[2.1-2.5]mmol/l, p = 0.51). We concluded that LDL-C level is low in patients with PAH and is associated with an increased risk of death. Reversal of PH increases LDL-C levels.
Related Papers
- → In Vitro Uptake of [3H]α-Tocopherol from Low Density Lipoprotein by Cultured Human Fibroblasts(1985)44 cited
- → Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins(1986)41 cited
- → Endotoxins Inhibit Endocytotic Catabolism of Low–Density Lipoproteins in Hep G2 Cells(1992)17 cited
- → The effect of ethanol on the lipoprotein metabolism of aortic smooth muscle cells(1986)1 cited
- → Cholesterol transfer between .ALPHA.- and .BETA.-lipoprotein fractions in serum. Method of estimation and some factors influencing the cholesterol translocation.(1988)