Inhibitory Potential of Constituents from Osmanthus fragrans and Structural Analogues Against Advanced Glycation End Products, α-Amylase, α-Glucosidase, and Oxidative Stress
Citations Over Time
Abstract
Inhibition of α-amylase and α-glucosidase, advanced glycation end products (AGEs) formation, and oxidative stress by isolated active constituents of Osmanthus fragrans flowers (9,12-octadecadienoic acid and 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one) and their structural analogues were evaluated. 9,12-Octadecadienoic acid was 10.02 and 22.21 times more active against α-amylase and α-glucosidase, respectively, than acarbose and ascorbic acid, followed by 9,12,15-octadecatrienoic acid, 9-octadecenoic acid, 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexenyl)-3-buten-2-one, 1-heptadecanecarboxylic acid, and 1-pentadecanecarboxylic acid. Concerning the inhibition of AGEs formation, similar with data for 2,2'-diphenyl-1-picrylhydrazl radical scavenging activities, 9,12-octadecadienoic acid was 3.54 times more active than aminoguanidine, followed by 9,12,15-octadecatrienoic acid, and 9-octadecenoic acid. These results indicate that 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one, 9,12-octadecadienoic acid and their analogues inhibit α-amylase and α-glucosidase, AGEs formation, and oxidative stress have potential value in alleviating diabetic pathological conditions.
Related Papers
- → An α-glucosidase inhibitor, acarbose treatment decreases serum levels of glyceraldehyde-derived advanced glycation end products (AGEs) in patients with type 2 diabetes(2009)34 cited
- → ChemInform Abstract: ON THE RADICAL SPECIES PRODUCED BY THE REACTION OF L‐ASCORBIC ACID AND ITS ANALOGS WITH HYDRAZINE AND ITS DERIVATIVES(1975)
- → ChemInform Abstract: STABLE L(+)‐ASCORBIC ACID RADICAL ANIONS(1978)
- → ChemInform Abstract: Radical Intermediates and Antioxidant Activity of Ascorbic Acid(1989)
- → ChemInform Abstract: Ascorbic Acid. Part 2. Structural Determination and Synthesis of 2‐ and 3‐Acyl Derivatives of 5,6‐O‐Isopropylidene‐L‐ascorbic Acid.(1989)