Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents
Journal of the Chemical Society Perkin Transactions 11999Iss. 10, pp. 1253–1256
Citations Over TimeTop 10% of 1999 papers
Abstract
A ten-step synthesis of (±)-epibatidine 1 is described, using an organised array of polymer supported reagents and sequestering agents in a successive manner. No chromatographic purification steps are required to afford the product in >90% purity.
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