An enantio- and stereocontrolled synthesis of (–)-mycestericin E via cinchona alkaloid-catalyzed asymmetric Baylis–Hillman reaction
Chemical Communications2001Iss. 19, pp. 2030–2031
Citations Over TimeTop 10% of 2001 papers
Abstract
A new enantiocontrolled synthesis of a potent immunosuppressant(-)-mycestericin E has been accomplished by using cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction of an aldehyde with 1,1,1,3,3,3-hexafluoroisopropyl acrylate and Lewis acid-promoted cyclisation of an epoxytrichloroacetimidate as the key steps.
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