Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides
Organic & Biomolecular Chemistry2003Vol. 1(4), pp. 648–654
Citations Over TimeTop 22% of 2003 papers
Miguel F. Braña, Mónica Cacho, Ana Ramos, M. Teresa Domínguez, José Manuel Pozuelo, Cristina Abradelo, Fernanda Rey-Stolle, Mercedes Yuste, Carolina Carrasco, Christian Bailly
Abstract
A novel series of mono and bisnaphthalimides was synthesized and their antiproliferative activities were evaluated against three tumor cell lines. Bisnaphthalimides 3 and 4, bearing a pyrazine ring fused to the naphthalimide system, showed activities in the order of 10(-8) microM, similar to elinafide. DNA binding properties and the ability to induce DNA damage were studied for some of the most active compounds.
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