Facilitation of addition–elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol
Chemical Communications2003Iss. 22, pp. 2802–2803
Citations Over Time
Hayley J. Whitfield, Roger J. Griffin, Ian R. Hardcastle, Andrew Henderson, Jérôme Meneyrol, Véronique Mesguiche, Kerry L. Sayle, Bernard T. Golding
Abstract
SNAr displacement reactions of 6-cyclohexylmethoxy-2-fluoropurine, 6-amino-2-butylsulfonyl-4-cyclohexylmethoxypyrimidine and 2-amino-6-chloropurine with substituted anilines (e.g. the weakly nucleophilic 4-aminobenzenesulfonamide) are dramaticallyaccelerated in the presence of trifluoroacetic acid and occur especially efficiently in 2,2,2-trifluoroethanol solvent.
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