Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives
Organic & Biomolecular Chemistry2005Vol. 3(16), pp. 3059–3059
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Florence O. McCarthy, Jay Chopra, Alan Ford, Sean A. Hogan, Joe P. Kerry, Nora M. O’Brien, Eileen Ryan, Anita R. Maguire
Abstract
Beta-sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
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