A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis
The Analyst2006Vol. 131(10), pp. 1075–1075
Citations Over TimeTop 10% of 2006 papers
Abstract
Metabonomic/metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample throughout the run, thereby enabling the analysis to be monitored and controlled using targeted inspection of the data and pattern recognition, is advocated as a pragmatic solution to this problem.
Related Papers
- → The role of sample preparation(2021)5 cited
- → Sample Preparation(2014)4 cited
- The improvement of bacteria sample preparation method for scanning electron microscope observation(2013)
- → Sample Preparation(2004)55 cited
- → Automatic Preparation System for Analysis Sample.(1992)