Detection of counterfeit tablets of an antiviral drug using δ34S measurements by MC-ICP-MS and confirmation by LA-MC-ICP-MS and HPLC-MC-ICP-MS
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Abstract
A new approach for pharmaceutical counterfeit detection using laser ablation multicollector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) and high performance liquid chromatography multicollector inductively coupled plasma mass spectrometry (HPLC-MC-ICP-MS) has been developed. Laser ablation and chromatographic separation parameters have been previously optimised and helium has been used as the carrier gas for better sensitivity. A homogeneity study of 288 pharmaceutical tablets from different batches of the genuine drug has been performed by MC-ICP-MS and characteristic sulfur isotopic signature has been obtained for the genuine product. δ34S measurements by MC-ICP-MS using silicon internal standardisation for the correction of instrumental mass bias effects led to a δ34S of 3.6‰ and an associated combined expanded uncertainty of 1‰ (k = 2).
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