Epigenetic remodeling of the fungal secondary metabolome
Organic & Biomolecular Chemistry2008Vol. 6(11), pp. 1895–1895
Citations Over TimeTop 1% of 2008 papers
Abstract
Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.
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