Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery
Chemical Communications2008Iss. 48, pp. 6570–6570
Citations Over TimeTop 1% of 2008 papers
Ahn Na Koo, Hong Jae Lee, Sung Eun Kim, Jeong Ho Chang, Chiyoung Park, Chulhee Kim, Jae Hyung Park, Sang Cheon Lee
Abstract
We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.
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